Studies on Copper Metabolism*
نویسندگان
چکیده
The results of studies on certain enzymes, hemin chromoproteins, and iron and copper in the tissues of normal, copper-deficient, and iron-deficient swine are reported in this paper. It has been suggested that the enzymes cytochrome oxidase (l-3), uricase (4), tyrosinase (5), plasma polyphenol oxidase (coeruloplasmin) (6), glutathione oxidase (7), and butyryl coenzyme A dehydrogenase (8) either contain copper or are associated with copper in their activity. Accordingly a study of the activity of these enzymes in the tissues has been included. The tissue hemin chromoproteins, cytochrome oxidase, cytochrome c, catalase, and myoglobin, were studied because of evidence from earlier work (9, 10) that hemoglobin synthesis is impaired and that copper influences the metabolism of iron. Inconsistencies and scarcity of reported data on the hemin chromoprotein content of the tissues in copper and iron deficiencies provided additional reasons for this study.
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